QuatRx Initiates Second Phase 3 Study Of Ophena(TM) (Ospemifene Tablets) In Women With Postmenopausal Vaginal Syndrome

�QuatRx Pharmaceuticals, a
privately-held biopharmaceutical company focused on development and
commercialization of compounds to treat internal secretion, metabolic and
cardiovascular disorders, announced that it has initiated a second
Phase 3 clinical trial of Ophena(TM) (ospemifene tablets), the company's
estrogen-free oral therapy in exploitation for the treatment of vaginal
symptoms associated with menopause.



The study is the instant pivotal Phase 3 clinical trial for Ophena(TM),
a new selective estrogen sensory receptor modulator (SERM) for the treatment of
postmenopausal vaginal syndrome (PVS), a common condition in postmenopausal
women. PVS, too known as vaginal atrophy, is characterized by progressive
long-term vaginal symptoms such as waterlessness, irritation and sexual pain
(dyspareunia). The first Phase 3 tribulation for Ophena(TM) met all the
co-primary endpoints at a 60 mg dose, with statistically significant
improvements in vaginal dryness and dyspareunia, as well as statistically
meaning improvement in the proportion of parabasal and superficial
cells in the epithelial tissue of vaginal walls and a decline in vaginal pH
levels.



The randomised, double-blind study will search to recruit 750
postmenopausal women at more than 100 trial centers throughout the United
States. Women participating in the study will be treated with either a 60
mg once everyday oral lucy in the sky with diamonds of Ophena(TM) or placebo over the 12-week intervention
period. All women testament also be supplied with a non-hormonal vaginal
lubricating substance to be applied as needed during the treatment period.



The co-primary endpoints of the study ar the change from baseline to
week 12 in the per centum of parabasal cells in the vaginal maturation
index, the percentage of superficial cells in the vaginal maturation index,
vaginal pH, and improvements in the most irritating moderate to severe
vulvovaginal atrophy symptoms of vaginal dryness and dyspareunia.



"We were identical pleased with the results of the first Phase 3 trial for
Ophena(TM) and conceive this following pivotal study will typify another
important development milestone for QuatRx," said Robert L. Zerbe, M.D.,
head executive officer and president of QuatRx. "For the large population
of postmenopausal women affected by progressive and pestiferous vaginal
symptoms, and specially those implicated about the health risks associated
with long-term estrogen-based therapy, we believe Ophena(TM) has the
potential to be an important new treatment option."

About Postmenopausal Vaginal Syndrome



Postmenopausal vaginal syndrome (PVS) is a inveterate and progressive
condition characterized by symptoms including vaginal dryness, sexual pain
(dyspareunia) and botheration. Declining oestrogen levels during menopause
can buoy cause tissues of the vaginal facing to mature thinner and to miss
elasticity, a condition known as withering. Dryness and irritation associated
with reductions in vaginal secretions oft cause pain sensation or hemorrhage during
sexual intercourse. It is estimated that 45-75 percent of post-menopausal
women experience inveterate symptoms of PVS. Current prescription treatments
approved for this circumstance all bear estrogen, administered either
orally or locally in the vagina. SERMs that ar currently approved and
marketed in the United States have non been shown to have beneficial
effects on vaginal tissue and none are approved for use in treating
symptoms of PVS.

About QuatRx



QuatRx Pharmaceuticals is focused on the discovery, licensing,
evolution and commercialization of compounds in the endocrine, metabolous
and cardiovascular therapeutic areas. In addition to Ophena(TM), QuatRx has
three other product candidates in active clinical development and an
advanced presymptomatic program. Fispemifene is a new selective estrogen
sensory receptor antagonist that is in Phase 2 studies as an oral treatment for the
symptoms of secondary hypogonadism in men. Sobetirome, a novel, selective
thyroid receptor beta agonist, is in Phase 1 as a potency treatment for
dyslipidemia. Becocalcidiol, a novel Vitamin D analogue, is in Phase 2
clinical trials for the treatment of psoriasis through QuatRx's partner,
Galderma. QuatRx's presymptomatic program is designed to address sex steroid
dependent diseases through inhibition of 17beta-HSD enzymes. In Europe,
QuatRx operates through its Finnish subsidiary company, Hormos Medical Ltd, placed
in Turku, Finland. For press releases and other Company info, please
chaffer http://www.quatrx.com.


QuatRx Pharmaceuticals
http://www.quatrx.com



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Zoledronic Acid Improves Bone-Mineral Density Loss In Premenopausal Patients Using Endocrine Therapies For Early Stage Breast Cancer

�
When at the same time administered, zoledronic acid partnered with
accessory endocrine therapy prevents pearl loss in women with breast
cancer, and improved bone-mineral tightness after handling, according to
an clause released on August 20, 2008 in The Lancet Oncology.�



For patients with early breast crab, endocrine therapy is used
routinely spell the tumors may inactive respond. One serious side effect
in premenopausal women on this treatment is bone loss, which has
received serious attention from clinicians. To quantify how endocrine
therapy affects bone-mineral density in the presence of co-occurrence
zoledronic acidulent, Professor Michael Gnant of the Medical University of
Vienna, General Hospital of Vienna, and colleagues performed a
prospective work of patients included in the�Austrian Breast
and Colorectal Cancer Study Group trial-12 (ABCSG-12.)


In this run, premenopausal women were randomised to have one of
two hormone therapies, either 3 years of goserelin plus tamoxifen or
goserelin plus anastrozole. Each of these groups were randomised to
receive concomitant zoledronic acid or without, making a tot up of four
subgroups. A total 404 women were included in this substudy, of whom
199 were assigned to endocrine therapy only, and 205 were assigned the
endocrine therapy with zoledronic acid. The women were evaluated for
lumbar-spine and trochanter bone-mineral density
using�dual-energy X-ray absorptiometry. Measurements were
taken at 0, 6, 12, 36, and 60 months, and the primary evaluated point
was the bone mineral density after one twelvemonth.


Patients world Health Organization were only administered hormone therapy had significant
bone-mineral density loss in comparability with their baseline evaluations
after 3 years. After 5 age, when the therapy regime had been
completed for 2 eld, some bone-mineral density recuperation was noted,
but non back to baseline levels. The patients on the concomitant
therapies, in contrast, remained unchanging with baseline values at 3
age, and had increased denseness after 5 years.


In conclusion, the authors note that victimization zoledronic acerbic in
combination with turn endocrine therapy in premenopausal,
early-stage breast cancer patients can potentially maintain their
bone-mineral tightness through this therapy and possibly meliorate bone
mineral density by and by. "The findings presented here offer important
information related to to os health for premenopausal women undergoing
adjuvant endocrine therapy," Notes Prof. Gnant.

Adjuvant endocrine therapy plus zoledronic acid in
premenopausal women with early-stage breast genus Cancer: 5-year review of
the ABCSG-12 bone-mineral density substudy
Michael Gnant, Brigitte Mlineritsch, Gero Luschin-Ebengreuth,
Franz Kainberger, Helmut Ka?ssmann, Jutta Claudia Piswanger-Solkner,
Michael Seifert, Ferdinand Ploner, Christian Menzel, Peter Dubsky,
Florian Fitzal, Vesna Bjelic-Radisic, Gu?nther Steger, Richard Greil,
Christian Marth, Ernst Kubista, Hellmut Samonigg, Peter Wohlmuth,
Martina Mittlbock, Raimund Jakesz, on behalf of the Austrian Breast and
Colorectal Cancer Study Group (ABCSG)
Lancet Oncol 2008; 9: 840-49

DOI:10.1016/S1470-2045(08)70204-3
Click Here For Journal


Written by Anna Sophia McKenney


Copyright: Medical News Today

Not to be reproduced without permission of Medical News Today


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Moguai

   
Artist: Moguai

   Genre(s): 
House
   

---

Discography:


   
 Moguai

   Year: 2004   
Tracks: 2


   
 Live @ Mayday

   Year: 2002   
Tracks: 1

---

 

Troy Pierce

   
Artist: Troy Pierce

   Genre(s): 
Electronic
   Techno
   Dance
   

---

Discography:


   
 Getting Lost EP

   Year: 2007   
Tracks: 10


   
 Run

   Year: 2005   
Tracks: 4


   
 Red Velvet Lines Black Box

   Year: 2005   
Tracks: 3


   
 25 Bitches (Vol. II)

   Year: 2005   
Tracks: 3


   
 25 Bitches (Vol. I)

   Year: 2005   
Tracks: 4

---

 

Spelling Doctor Plans Jolie Trip

The doctor who delivered Tori Spelling's baby daughter on Monday is set for a busy summer - he's also booked to oversee Angelina Jolie's pregnancy. Dr. Jason Rothbart took charge of Spelling's C-section at Cedars-Sinai Medical Center in Los Angeles, and the obstetrician/gynaecologist is now reportedly planning a trip to France where he'll attend to another second-time mum, Jolie. Rothbart stayed in Namibia with the star to deliver her first biological child, Shiloh, who is now two. Jolie is due to give birth to twins later this summer .


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Toy Dolls

   
Artist: Toy Dolls

   Genre(s): 
Punk
   Alternative
   Rock: Punk-Rock
   

---

Discography:


   
 One More Megabyte

   Year: 2005   
Tracks: 14


   
 Our Last Album?

   Year: 2004   
Tracks: 16


   
 Ten Years Of Toys

   Year: 2002   
Tracks: 16


   
 Anniversary Anthems (Japan)

   Year: 2000   
Tracks: 15


   
 On Stage In Stuttgart

   Year: 1999   
Tracks: 25


   
 Orcastrated

   Year: 1995   
Tracks: 14


   
 Absurd Ditties

   Year: 1993   
Tracks: 14


   
 Singles 83-84

   Year: 1992   
Tracks: 7


   
 Idle Gossip

   Year: 1992   
Tracks: 12


   
 A Far Out Disc

   Year: 1992   
Tracks: 16


   
 Fat Bob's Feet

   Year: 1991   
Tracks: 15


   
 Twenty Two Tunes Live From Tokyo

   Year: 1990   
Tracks: 22


   
 Twenty Two Tunes Live From Tok

   Year: 1990   
Tracks: 22


   
 Wakey Wakey!

   Year: 1989   
Tracks: 14


   
 Bare Faced Cheek

   Year: 1987   
Tracks: 12


   
 Dig That Groove Baby

   Year: 1983   
Tracks: 14


   
 Bonus

   Year:    
Tracks: 9

---

Long-lived spunk outfit Toy Dolls formed in Sunderland, England, in October of 1979, in the beginning comprising isaac Bashevis Singer Pete Zulu (born Peter Robson), guitar player Olga (Michael Algar), bassist Flip (Duke of Edinburgh Dugdale), and drummer Mr. Colin Scott. Within a month, and afterward just a handful of gigs, Zulu left the mathematical group, the low gear in a apparently dateless identification number of card changes to follow in the sexual climax age; with novel frontman Hud lasting just now one live date, Olga in agreement to acquire vocal duties, and the leftover Toy Dolls continued as a triad. By the time the group's debut single, "Tommy Kowey's Car," followed in mid-1980, Mr. Scott had exited the lineup as well, with a procession of drummers filling in earlier the comer of Teddy Toy Doll (aka Graham Edmundson) toward the end of the twelvemonth. A handful of compilation tracks including "She's a Worky Ticket" and "Deirdre's a Slag" (a potshot at Enthronization Street virtuoso Deirdre Barlow) farther cemented Toy Dolls' absurdist leanings, and following the exit of Teddy Toy Doll the group tapped drummer Happy Bob (aka Robert Kent, world Health Organization had previously teamed with Olga in the Showbiz Kids) as his successor, issuing a self-financed, self-titled EP in September of 1981.


The individual "Everybody Jitterbug" appeared on EMI the future spring, and in 1983 Toy Dolls issued their long-awaited full-length debut, Dig That Groove Baby. After a enlistment in support of the Angelic Upstarts, both Flip and Happy Bob left the band, however, leaving Olga the sole surviving original member; the revolving lineups continued, just in 1984 a re-recorded version of the before single "Nellie the Elephant" contract with bassist Bonny Baz (Barry Warne) and drummer Dicky (Malcolm Dick) reached the Top Five on the U.K. pop out charts. The LP A Far Out Disc followed in 1985, trailed a twelvemonth by and by by Idle Gossip; despite the usual force turnover, the group noted its number 1 decennary of existence in 1989 with Ten-spot Years of Toys. Amazingly sufficiency, another strong x of new music was forthcoming, with few changes to the band's creative access and legion changes to their roster. Cleopatra Records feted the lot on its twentieth anniversary with the release of the best-of collection The Wonderful World of the Toy Dolls.





JENNY SCHEINMAN

Bonnaroo to be televised for first time

The Bonnaroo Music & Arts festival is going to be nationally televised for the first time this year, it was announced today (May 19).

The annual Tennessee event features headliners Kanye West, Pearl Jam and Metallica. Now those unable to attend the three-day festival have the option to watch it from their own homes on national cable television channel Fuse TV.

Fuse plans to televise six hours of programming from the festival, ranging from performances to interviews with the artists, and will broadcast live from the event, reports the Associated Press.

The festival is set to take place June 12-15 in Manchester, Tennessee and also includes performances by MIA, My Morning Jacket, Vampire Weekend, !!!, Death Cab For Cutie, Sigur Ros, Rilo Kiley and The Raconteurs, as previously reported.

--By our Los Angeles staff.
Find out more about NME.

Derek Luke - Fascinating Fact 5223

Movie star DEREK LUKE plays ALICIA KEYS' boyfriend in her new video TEENAGE LOVE AFFAIR.

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Lisa Stansfield

   
Artist: Lisa Stansfield

   Genre(s): 
Rap: Hip-Hop
   Rock: Pop-Rock
   Dance: Pop
   Soundtrack
   Other
   

---

Discography:


   
 The Moment

   Year: 2005   
Tracks: 11


   
 Face Up

   Year: 2003   
Tracks: 13


   
 Real Love

   Year: 2001   
Tracks: 13


   
 Swing

   Year: 1999   
Tracks: 15


   
 Lisa Stansfield

   Year: 1996   
Tracks: 16


   
 So Natural

   Year: 1993   
Tracks: 13


   
 Affection

   Year: 1989   
Tracks: 13


   
 Biography: Greatest Hits (CD 2)

   Year:    
Tracks: 6


   
 Biography: Greatest Hits (CD 1)

   Year:    
Tracks: 17

---

English people vocalist Lisa Stansfield was the hint isaac Bashevis Singer of the mathematical grouping the Blue Zone and featured on Coldcut's "The great unwashed Have got On" in 1989. She zoomed into the spot with Eye in 1990. The album went atomic number 78 and earned her a return trio pop and identification routine one R&B ace with "Entirely Around the Domain." Warmness and its follow-up, Real Love, were deep influenced by the '70s disco strait of Barry Patrick Victor Martindale White, from arrangements to mode and layer Stansfield's possess proficiency. After a long hiatus, she returned with a self-titled stew in 1997. The #1 Remixes EP followed a year later.

Madonna set for Rock Hall of Fame

Madonna set for Rock Hall of Fame

Madonna Louise Ciccone is to be inducted into the Rock-and-roll and Rock and roll Hall of Fame next year.
Billboard reports that she testament unite fellow inductees Gospel According to John Mellencamp, Leonard Cohen, the Ventures and the Dave William Clark Five-spot for the 2008 ceremonial, which will be held on 10 Mar at New York's Waldorf Astoria hotel.
Artists become eligible for installation into the Rock and Stray Hall of Renown 25 eld after the release of their debut single or album.
Madonna's new album is due come out next give.

Tellier bows to French Euro vision

Tellier bows to French Euro vision

Sebastien Tellier has broken his muteness over Eurovisiongate (as we've chosen to call it) and pledged to include around more French lyrics in his entree for this year's contest, to the respite of a vexed carry Nation.As we told you yesterday Tellier will be representing Jacques Anatole Francois Thibault at Eurovision next month, and his song is called Jehovah. It was selected by the France-3 TV network. And it is sung dynasty near all in English people.










French people minister Alain Joyandet, a extremity of the council of ministers, the equivalent of Britain's cabinet, is amongst those wHO hold condemned the racecourse - which includes only when 2 lines in French. "When unity has the accolade of beingness selected to represent Anatole France, one sings in French," he said.Directly Tellier, in true French fashion, appears to have surrendered. "If it makes everyone happy, of course I'll make an elbow grease," he lastly announced yesterday. "I just want to please people."Only spell he is capitulating to the public's demands, Tellier doesn't seem excessively happy with the situation. "If I had been asked to do a strain expressly for Eurovision, I clear would have done something in French," he explained. "I'm not dense."In case anyone was in dubiousness as to his Frenchness, Tellier likewise underlined the head with a Cantona-esque metaphor. "The baguet won't appreciation any worse tomorrow good morning if I sing in English language," he said. Which would itself make a kinda catchy chorus.





Russian Circles

Isilon Systems to Showcase Future of Digital Media at NAB 2008

Isilon Systems to Showcase Future of Digital Media at NAB 2008

'Isilon 3D Theater' To Provide Hook Preview of Next-Generation 3D
Broadcasting

LAS VEGAS, Apr 14 /PRNewswire-FirstCall/ -- (Nab, Booth #SU8525) --
Isilon(R) Systems (NASDAQ: ISLN), the loss leader in clustered entrepot, will
provide a glimpse into the time to come of the digital media landscape at the
2008 Subject Association of Broadcasters (Nab) conference in Las Vegas
from April 14th - 18th. Underscoring the critical role clustered computer memory
serves in empowering the next contemporaries of digital media, Isilon will
feature two marquise demonstrations at Arrest 2008. In conjunction with
Isilon's client, 3ality Digital Systems, Isilon will confront the "Isilon
3D Theater" featuring a screening of live-action 3D transmit scheduling,
including a segment of the motion picture U23D. At Isilon's Nab booth, the troupe
has joined with Tekserve Professional person and Gallery/Sienna to establish how
tomorrow's newsrooms will wangle, edit and acquire HD programing in
real time using Isilon clustered computer storage in combination with Apple Final examination
Cut Pro product environments.

"The demands of digital 3D amusement are an order of magnitude
larger than traditional digital media and so, in guild to maintain push the
digital media envelope, a newly paradigm in storehouse is required," said Howard
Postley, CTO of 3ality Digital Systems. "By deploying Isilon IQ, we have
been able to amalgamate disparate silos of 3D capacity into a single, highly
scalable shared pool of computer memory, which is critical for delivering a
seamless 3D viewing see."

One of the almost talked around trends in the entertainment industry is
the arrival of 3D entertainment, which has been widely regarded as a genuinely
immersive entertainment live which promises to impact both the film
and send industries. To bring home the bacon Nab attendees with a prevue of what
the stereoscopic 3D future will await like, Isilon and 3ality, the creators
of the groundbreaking technology which was used to celluloid U23D, are
presenting the "Isilon 3D Dramaturgy" at Nab. The masking of 3D music and
sports programing volition be streamed in 2 concurrent uncompressed HD
streams directly from an Isilon IQ storage bunch. The demonstration will likewise
show window the latest in 3D moving-picture show production technologies acting back two
uncompressed HD (correctly eye/left centre) streams to a projector in the room
direct from an Isilon IQ constellate.

"Next-generation media, near notably high-definition and 3D, is rapidly
becoming an everyday reality, creating groundbreaking freshly opportunities in
digital media for pioneering companies to deliver never-before-seen
amusement to viewers," said Brett Goodwin, VP of Marketing & Business
Development, Isilon Systems. "In conjunction with customers and partners,
our demonstrations at Nab highlight multiple aspects of next-generation,
digital media. From the broadcast view, Isilon IQ provides
tomorrow's newsroom with superior flexibleness and responsiveness, spell on
the depicted object delivery side of meat, capacity creators nates at present bring their 3D visions
to world through the power of clustered storage."

Driven by the incredible soar up in sales of high-definition flat screen door
displays, and the increasing ubiquity of high-speed Net access across
TVs, PCs and mobile devices, diffuse computer programming is now organism created,
managed, delivered and archived digitally, end-to-end. Not exclusively ar
broadcasters managing significantly larger digital files merely in an age of
breaking news and high-definition scheduling, production teams cannot
afford to hold back for production servers to assimilate data ahead editing altogether
footage. Isilon has joined with Tekserve Professional person and Gallery/Sienna to
present a fill out automation workflow solution built around the Final
Reduce Pro editing entourage. Together with these leading media companies, Isilon
will show how broadcast IT organizations canful implement this
integrated solution to machinate for the proliferation of HD substance
passim the industry.

Powered by OneFS(R), Isilon IQ delivers the industry's first single
file system that unifies and provides second and ubiquitous access to the
quickly ontogeny stores of digital depicted object, eliminating the cost and
complexness barriers of traditional storage architectures. OneFS is a
unified operating system computer software layer that powers altogether of Isilon's
award-winning family of IQ clustered storage systems including the Isilon
IQ 200, 1920, 3000, 6000, 9000, 12000, Throttle, and EX 6000, 9000 and
12000. Isilon likewise provides a robust cortege of software system applications
including SnapshotIQ(TM), SmartConnect(TM), SmartQuotas(TM),
MigrationIQ(TM) and SyncIQ(R) that leveraging OneFS and clustered memory board,
providing the highest levels of data protection and automated data
management.

Just about Isilon Systems

Isilon Systems (NASDAQ: ISLN) is the worldwide drawing card in clustered
memory systems and software system for digital content and unstructured information,
enabling enterprises to transform information into data -- and information
into breakthroughs. Isilon's award-winning family of IQ clustered storage
systems combines Isilon's OneFS operating scheme software with the latest
advances in industry-standard hardware to deport modular, pay-as-you-grow,
enterprise category depot systems. Isilon's clustered computer storage solutions
amphetamine access to critical business information piece dramatically reducing
the cost and complexness of storing it. Information about Isilon commode be
launch at hypertext transfer protocol://www.isilon.com.

The name calling of companies mentioned herein are the trademarks of their
respective owners.

Decypha

   
Artist: Decypha

   Genre(s): 
Jazz: Funk
   

---

Discography:


   
 SouthernGumboFunkMusiq

   Year: 2004   
Tracks: 3

---

 

Arcade Fire to sue TV station?

Arcade Fire to sue TV station?

Arcade Fire ar reportedly considering pickings legal legal action against the Fox TV meshwork for victimisation their music without license during Sunday's Super Bowl in Grand Canyon State.
According to music website Pitchfork, Fox did non ask the Canadian band if it could use their bump off 'No Cars Go' on the cite for the National Football League, which aired during the half time show.
The band's representatives ar currently considering whether they should pursue the matter.